This revealed that tamoxifen markedly augmented the specific phasic force of Mtm1−/y mice (+155%), reaching 61% of the force developed by WT mice.
We conclude that a single exercise bout in healthy donors markedly augments the ex vivo expansion and anti-tumor activity of gamma-delta T-cells.
These biochemical effects mimicked those of a pharmacological histone deacetylase inhibitor, valproic acid (VPA), and like VPA markedly augmented the expression of cardiomyocyte-specific proteins by the genetically engineered cells.
We could show that this defect markedly augments the susceptibility to pulmonary edema of these mice.
Pretreatment with SSO to inhibit FAT/CD36 markedly augmented the proportion of palmitate-treated cells with subplasmalemmal GFP signal.
In agreement with this previous observation, we found that RLX treatment markedly augmented the staining of MMP-11 in the wounds.
Further, BSO markedly augmented the activation of caspase 9, which is triggered by released cytochrome c and is involved in an early stage of mitochondrial apoptosis.
PEA could markedly augment the effect of AEA at cannabinoid receptor type 1 and/or 2, as well as directly activate peroxisome proliferator-activated receptor alpha constitutively, and simultaneously control both "passive" and "active" skin functions, including regeneration of skin and restoration of lipid lamellae, skin sensation, and immune competence.
Dietary capsaicin did not affect the blood pressure (data not shown) but markedly augmented the endothelium-dependent relaxation observed in both the aorta and mesenteric arteries (MA) of db/db mice (Aorta Emax: 45.59 ± 2.35 in control vs 71.07 ± 3.02 in capsaicin-administered mice, P<0.01; MA Emax: 50.36 ± 3.73 in control vs 62.94 ± 2.68 in capsaicin-administered mice, P<0.05).
Moreover, the activating effect of TNF-α was markedly augmented by the infection of Helicobacter pylori, the primary cause of human gastritis.
