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The dissolution rate of tacrolimus was markedly augmented by the complexation with DM‐β‐CyD, reflecting its solubilizing activity.
The monocyte chemotactic and polarizing activity of supernatants of IL-1-treated HEC (presumably related to colony-stimulating factors being released by HEC) was markedly augmented by absorption on immobilized anti-p15E antibodies.
CHOP induction was markedly augmented by PARM-1 silencing, while activation of JNK and Caspase-12 was unaffected (Fig. 5B,C), indicating that PARM-1 was also mediating prosurvival effect by suppressing CHOP-mediated apoptotic pathways in cardiac myocytes.
As before, intratumoral injections of pSP-D-CD40L alone slowed tumor growth (Fig. 5A) and prolonged survival (Fig. 5B), and the antitumor effect was markedly augmented by combination with CpG and especially CpG + poly(I C).
24– 26 NK cell cytotoxicity for lung cancer cells was markedly augmented by stimulation with IL-2.
Moreover, the activating effect of TNF-α was markedly augmented by the infection of Helicobacter pylori, the primary cause of human gastritis.
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These biochemical effects mimicked those of a pharmacological histone deacetylase inhibitor, valproic acid (VPA), and like VPA markedly augmented the expression of cardiomyocyte-specific proteins by the genetically engineered cells.
Further, BSO markedly augmented the activation of caspase 9, which is triggered by released cytochrome c and is involved in an early stage of mitochondrial apoptosis.
Lipoprotein profiling by fast protein liquid chromatography (FPLC) supported markedly augmented plasma TRL levels in cold-exposed Angptl4-Tg mice.
Quantitatively, left ventricular mass (LVM) was markedly augmented in the AAB group compared with its respective control by 4 weeks post surgery (17%) and this increase was maintained over 9 (14%) and 14 weeks (14%), irrespective of dietary manipulation.
They observed that the signal generated by Integrin αV β3-targeted microbubble was markedly augmented at 4 days after ligation in FGF-2 treated group, coinciding with a greater angiogenic response.
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