Sentence examples for markedly altered during from inspiring English sources

Cell-associated and tumor microenvironment GAG content and distribution is markedly altered during tumor pathogenesis and progression [ 11, 12].

Indeed, circulating amounts in testosterone, androstenedione, dehydro-epiandrosterone (DHEA), and DHEA-sulfate (DHEAS) are not markedly altered during premenopause.

Importantly, cell-associated and tumor microenvironment glycosaminoglycans (GAGs)/proteoglycan (PG) content and distribution are markedly altered during tumor pathogenesis and progression.

The expression of HSPGs is markedly altered during malignant transformation and tumor progression, affecting both the PG core proteins and the GAG chains [ 30].

Even though the samples presented heterogeneous expression profiles, our results show that the transcriptional profile of the PTGS pathway is markedly altered during tumorigenesis, presenting downregulation of many genes in the majority of tumors (Fig.  1a).

To my knowledge, the degree to which a change in viscosity would further affect afterload or venous return, when the mechanoreceptor function of the endothelium is markedly altered during an inflammatory state, has not been studied in the clinical setting.

The Mx1, ISG20 and IFITM1 also displayed markedly altered mRNA levels during IBV infection.

This study suggests that important stretch responses of collagen made possible by collagen crimping may be markedly altered by morphologic changes during aging/degeneration and may contribute to the early tissue changes involved in annular tears.

In preweaning rats righting reflex and cliff avoidance tests were markedly altered following repeated, low-level CPF exposures during late gestation [ 24].

Although proteoglycan loss has long been acknowledged to be an important part of disc aging and degeneration, the work presented here suggests that important stretch responses of collagen made possible by collagen crimping may be markedly altered by morphologic changes in disc architecture during aging/degeneration; such changes may contribute to the early tissue changes involved in annular tears.

Inactivation of Dicer1 during secondary fiber differentiation produced degenerated lenses, and the markedly altered miRNA profiles in response to activated FGF signaling in lens cell culture systems further substantiate key cell-autonomous roles for miRNAs in the maintenance of the lens epithelium compartment and for the differentiation of lens fiber cells (Wolf et al., 2013a).