Sentence examples for markedly aggravated from inspiring English sources

These results suggest that the intestinal ulcerogenic response to indomethacin is markedly aggravated in arthritic rats.

We found that although the detrimental effects of maternal HFD consumption on offspring depressive behavior did not persist into adulthood, it markedly aggravated the behavioral disorder response to stressful challenge in adult offspring.

Our Ang II experiments showed that Ang II markedly aggravated the already-present cardiac fibrosis.

Our results showed a markedly aggravated atherosclerotic phenotype of FGF21 knockout mice, which can be reversed by replenishment of FGF21.

In contrast, the diabetic state markedly aggravated MCAO/Re-induced cerebral damage despite ETN treatment within 24 h before MCAO.

We demonstrated that acid-reflux esophagitis was markedly aggravated by indomethacin as well as SC-560, but not rofecoxib [ 16].

Conversely, there are certain advantages to studying OP in rabbits [ 32] and, in this context, our group has developed an experimental model in mature rabbits where OP markedly aggravates the severity of OA estimated using the Mankin score.

Biofilm formed by bacteria may thus markedly aggravate implant-related infection, and the establishment of an appropriate treatment method is awaited.

According to the criteria, the headache must have developed during the medication overuse period, or the primary headache shall have aggravated markedly, but it is often difficult to obtain this information as these chronic headaches may have persisted for a very long period of time.

Moreover, both RSV and EX527 markedly inhibited or aggravated the AGE-mediated TGF- β upregulation.

H2O2 PC and PoC at moderate concentrations, higher than a level that aggravated reperfusion injury, markedly induce cardioprotection via efficient activation of downstream prosurvival signaling pathways, whereas they induce a comparable level of ER stress as the lower concentration of H2O2 PC or PoC.