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Although only one marker in each high LD cluster was kept for calculating marked variance in order to reduce bias, caution still needs to be exercised when interpreting this variance since it was obtained from unshrunken estimates of marker effects with simple regression approaches.
The six included studies showed a marked variance in ADC values of thyroid nodules.
While a strong rationale supports this approach, study results are difficult to interpret and compare due to marked variance in multiple aspects of study design and performance.
Despite the marked variance in the primary structures, it has been found that all of these enzymes contain a catalytic triad, which is conserved in the invariant order of nucleophile-acid-histidine (but except from the histidine, the amino acid identities can vary) [ 14- 16].
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Rahier et al. (3) observed marked variance between the body and tail within individuals not seen in a prior study (17) or in our own studies of pancreas procured from brain-dead organ donors.
With these "uniquely" significant markers, marked variance was then computed according to Eqs. 7 and 8.
Marked variance changed from 1.218 ×10−4 to 1.842 ×10−4 when imprinting was considered in the analysis, implying that one third of marked variance would be lost if existing imprinting effects were not accounted for.
Marked genetic variance in inbred mouse strains has been observed for sucrose intake across a wide array of concentrations in terms of sensitivity, magnitude, percentages of kilocalories consumed as sucrose and compensatory chow intake.
On subsequent analysis, it became clear that although this study was methodologically well designed, there was marked inter-centre variance in the treatment effect of hypothermia, age of participants, severity of illness scoring between groups, management of intracranial hypertension, and haemodynamic and fluid management [ 64].
There was also a marked reduction in the variance across the replicates for the colorectal DSA compared to the Plus2.0 array suggesting a greater degree of reproducibility for the Colorectal DSA.
The between-tray design precluded any influence of inter-trial variance, and found marked overlap in the trays' confidence intervals across the experiment, suggesting no preference for any tray.
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