Sentence examples for marked toxicity was from inspiring English sources
Resveratrol seems to be well tolerated and no marked toxicity was reported.
Two diguanides, synthalin A and synthalin B, were used clinically, but marked toxicity, which could not be dissociated from therapeutic effects, was noted quite quickly [ 11, 12].
In vivo, utilising a mouse model grafted with prostate carcinoma, significant tumour suppression was achieved using PEGylated complexes without marked toxicity or undesirable immunological response, this was accompanied by a simultaneous reduction in target mRNA levels.
Short-term exposure to high H2O2 levels induced marked toxicity, suggesting that under these experimental conditions necrosis was the predominant mode of cell death.
This may be the reason why NAC containing CPT-11 showed a higher efficacy without marked toxicity in patients with heterozygous polymorphisms.
Although, the chemical agents showed a profound anti-fibrotic potential, they exhibited marked toxicity on hepatocytes.
After the second dose of ipilimumab, marked worsening of skin toxicity was noted, with a grade 3 pemphigoid rash and bullous lesions involving the upper and lower extremities.
Bladder toxicity was more marked both during and after treatment in the 1.5 cm margin group (P=0.002, P=0.02, respectively) as seen in Table 4 and Figure 3D.
Jackson later acknowledged, "How much toxicity was introduced?
I doubt very much that its toxicity was very much known".
