At the highest dose tested, 400mg, there was "marked suppression" of the hormones required for sperm production, she said.
After nine months of combined therapy, marked suppression of immunoreactive PTH occurred in the absence of hypercalcemia.
In HJV-null (Hjv mice that have severe iron overload and marked suppression of hepcidin expression, we detected 4-fold higher hepatic BMP6 mRNA than in wild-type counterparts.
Overexpression of TGF-β1 in a murine MMTV model of mammary cancer demonstrated marked suppression of tumor formation [17].
Our results clearly demonstrate that subchronic Boc5 treatment invoked marked suppression of food intake and sustained reduction of body weight in DIO mice with both 1 mg and 3 mg doses (Figures 1A, 1C and 1D).
As shown in Fig. 3b, we observed marked suppression of B16-F10 melanoma growth implanted into the dermis.
Cells with either de novo log-fold resistance to obatoclax, or selected for resistance to obatoclax, exhibited marked suppression of apoptosis.
In the CIA model a marked suppression of synovial gene expression of bFGF and VEGF was observed, with parallel reduction of synovial blood vessels, whereas in both CIA and AIA the severity of disease was reduced.
Histological and physiological analyses of BAT showed in adult wild-type mice, a marked suppression of BAT growth concurrent with a prominent decrease in lipolytic and thermogenesis activities.
This protection is mediated by CD8 T cells, which specifically kill FLK-1+ endothelial cells, resulting in marked suppression of tumor angiogenesis.
