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Although MDD is highly prevalent in adolescents and is associated with marked suffering, impairment and risk of suicide, the scientific data regarding the safety and efficacy of treatments for pediatric depression are limited.
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Accept the Four Noble Truths which are: All life is marked by suffering; Suffering is caused by desire and attachment; Suffering can be eliminated; Suffering can be eliminated by following the Noble 8-Fold Path.
It is the truth that life is, ultimately, not satisfactory - that it is marked by suffering.
I totally see how the Buddha can see everything is marked by suffering.
On the evidence, Ricky has not yet hit his mark: suffering in silence, then exploding.
These are moments marked by pain, suffering, excitement, confusion, and concern.
One had gone through the trauma of "shell shock", and all had been marked and seared, suffering from the guilt of surviving a catastrophe that had consumed their generation, their class and their country.
Luka Modric is another doubt for coach Carlo Ancelotti, as the midfielder had to be withdrawn on the hour mark after suffering a heavy blow to his knee.
Matthew Upson was forced to come off the pitch before the half-hour mark, after suffering a knee injury.
They are not just marked by their suffering; they are nothing more than their suffering, and therefore on some basic level they are faceless.
At times, he called on the familiar metaphor of American blacks as modern-day equivalents of the ancient Hebrews, a people marked by terrible suffering and displacement.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com