Sentence examples for marked side effects from inspiring English sources

Therefore, therapy regimens including non-genotoxic Mdm2 or proteasome inhibitors may be as effective as cytotoxic therapies for treatment of TGCT with wtp53 status, thus avoiding the relatively marked side effects of Cisplatin such as nephrotoxicity and neurotoxicity [44], [45].

Due to the sometimes marked side effects in standard chemoradiation regimens using altered-fractionation 3 D conformal radiation techniques, intensification is rarely clinically possible.

Retrospective comparison of the data with prior radiochemotherapy studies showed comparable clinical results without the sometimes marked side effects of the chemotherapy approach [ 22].

However, with the introduction of chemotherapy during the late 1950s and its proven effects in advanced ovarian cancer (yielding the best primary response rate), radiotherapy has been more and more abandoned mostly due to marked side effects [ 20].

Mild hypothermia represents one of the most challenging aspects of prevention of organ failure [ 53], since it can improve outcome but may also be associated with marked side effects [ 54, 55].

However, PEG-IFNα therapy presents marked side effects [ 15] and ~40 % sustained virologic response [ 16].

Radiotherapy of head and neck cancer is commonly accompanied by marked side-effects.

However, the marked acute psychological side effects of ketamine complicate the interpretation of both preclinical and clinical data.

Vytorin, by combining Zocor and Zetia, produces a bigger drop in cholesterol than either drug could do alone, and without a marked increase in side effects.

Some authors suggest that modifying the aminoalkyl side chain into heterocyclic structures still preserves the basic  β-phenethylamine structure and retains the central stimulant activity without marked anorexigenic and cardiovascular side effects [ 14].

77, 78 Their effectiveness and side effects are somewhat less marked because of a shorter half-life, but basically the same reservations apply.