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We provided further evidence for the marked sequence diversity among aHEVs by providing the nearly complete genome sequence of a strain identified during a BLSD outbreak in Hungary.
It is intriguing that marked sequence diversity within the catalytic regions of some of the splice variant kinases result in kinases belonging to different subfamilies.
These findings are highly unlikely to represent amplicon contamination since marked sequence diversity was observed, and since only a single tick from each pool was positive in each reaction.
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Although in the genus Hepevirus no species demarcation criteria have been defined, the marked sequence diversities suggest that the rat HEV represents an additional virus species other than HEV-1, HEV-2, HEV-3, HEV-4, and the tentative species avian HEV, which are currently classified in this genus (14 ).
Thus, pandemic (H1N1) 2009 virus was unique among serotypes in showing a marked difference in sequence diversity between HA and NA.
This would explain their polyphyletic distribution on the β-amylase tree, their sequence diversity, and their marked similarities to elements at non-homologous sites in other genomes.
First, patterns of variation of X-linked and autosomal diversity depend heavily on sequence type, which suggests that the evolutionary forces responsible for the generation and maintenance of sequence diversity are heterogeneous across the genome, with marked differences between sequences that are either genic or in close proximity to genic sequence and regions that are distant to genes.
Eight related mutants with greater sequence diversity were also constructed.
Average DNA sequence diversity within each ORSC subpopulation.
Viral sequence diversity proved accurate in estimating time of infection.
Other selective forces may generate alternative effects on sequence diversity.
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