Sentence examples for marked sensitization of from inspiring English sources

Of note, mutant Mn-SOD heterozygous knockout mice exhibit marked sensitization of the mitochondrial permeability transition pore (mPTP) and premature induction of apoptosis.

Since ROS is a known sensitizing stimulus for mPTP opening in vivo [39], this increase in H2O2 production may also contribute to the marked sensitization of mPTP opening to Ca2+ in the isolated mitochondria.

Second, we also found that time to mPTP opening was 98% shorter in isolated mitochondria compared to permeabilized myofibers (21 vs 977 seconds, respectively) (Figure 2D) and the amount of Ca2+ necessary to trigger opening of the mPTP was 42% lower in the isolated preparations (Figure 2E), demonstrating a marked sensitization of the mPTP to a Ca2+ challenge in isolated mitochondria.

CD44v7-10 RNAinin PC-3M cells caused marked sensitization to Docetaxel; the two CD44s re-expression approaches caused minimal sensitization.

These cellular data could be recapitulated biochemically by the addition of bacterial neutral sphingomyelinase or recombinant human neutral sphingomyelinase to isolated mitochondria, which also caused marked sensitization to pro-apoptotic stimuli.

Furthermore, from the Pearson's analysis it also emerged that the more this sequential thalamic and cortical HF oscillatory activation increased, the more marked the sensitization of the LF-SSEP N20-P25 1st amplitude block.

Marked sensitization was again observed, with only a slight decrease in extent of sensitization (~2 fold) compared to a 24 h concurrent treatment.

Atopic sensitization was common in all groups, especially the severe asthma group This tendency was most marked for dog sensitization (Table 2).

Sensitization of mice to methylphenidate.

Sensitization of locomotion following repeated ventral tegmental injections of cytisine.

Sensitization of ACHN cells to TRAIL-induced apoptosis by rocaglamide.