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The 14th tumour, a slow-growing sarcoma, was not sensitized under ambient conditions, but showed marked sensitization when clamped to produce acutely hypoxic cells.
A stronger stimulus, especially one, such as food or shock, that has substantial significance to the animal, may show marked sensitization and relatively little habituation.
Of note, mutant Mn-SOD heterozygous knockout mice exhibit marked sensitization of the mitochondrial permeability transition pore (mPTP) and premature induction of apoptosis.
CD44v7-10 RNAinin PC-3M cells caused marked sensitization to Docetaxel; the two CD44s re-expression approaches caused minimal sensitization.
These cellular data could be recapitulated biochemically by the addition of bacterial neutral sphingomyelinase or recombinant human neutral sphingomyelinase to isolated mitochondria, which also caused marked sensitization to pro-apoptotic stimuli.
Marked sensitization was again observed, with only a slight decrease in extent of sensitization (~2 fold) compared to a 24 h concurrent treatment.
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Furthermore, from the Pearson's analysis it also emerged that the more this sequential thalamic and cortical HF oscillatory activation increased, the more marked the sensitization of the LF-SSEP N20-P25 1st amplitude block.
Although mutations furE90A, E110N and Y65N each caused marked Mtz sensitization 16R-50RR range), double mutants containing furY65N and also furE90A or Q or E110N, R or P each conferred a Δfur-like 160R,190S phenotype (data not shown).
Atopic sensitization was common in all groups, especially the severe asthma group This tendency was most marked for dog sensitization (Table 2).
As Ca2+ sensitization i.e. alteration of the relationship between force and [Ca2+] appears not to be marked in myometrium under physiological conditions (e.g. [24]), changes in excitability i.e. membrane potential appeared the most likely cause of increased Ca2+ and force with SR Ca2+ depletion.
This is not surprising, as the comparison is between two groups (ESO, ASO) that both exhibit marked eosinophilic airway inflammation following classic OVA sensitization/challenge.
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