Sentence examples for marked sensitivity to from inspiring English sources
Small crack growth resistance had a marked sensitivity to microstructural features, such as α/α grain boundaries with high misorientation and α/α + β boundaries.
ALT+ tumors acquired amplification/overexpression of PGC-1β, a master regulator of mitochondrial biogenesis and function, and they showed marked sensitivity to PGC-1β or SOD2 knockdown.
An even more marked sensitivity to epothilone B relative to paclitaxel was recently shown in two human melanoma cell lines [10].
Thus, expression of mre11-H59A conferesistantstont to ETP and CPT, despite marked sensitivity to HU and IR; and expression of mre11-H125N strain conferred resistant to ETP, despite sensitivity to CPT, HU and IR.
Marked sensitivity to sulfonylureas resulting in hypoglycaemia despite poor glycaemic control before starting sulfonylureas [ 9, 30].
Ligase IV-deficient embryonic fibroblasts also show marked sensitivity to IR (Frank et al, 1998).
Despite the marked sensitivity of the medulloblastomas to the epipodophyllotoxins, three early passage cultures were much more resistant to these drugs than the average for the group.
An example of this strategy is represented by marked sensitivity of MM cells to poly(ADP-ribose) polymerase (PARP) inhibitors triggered by 26S proteasome inhibition.
Moreover, the observed marked sensitivity of resistant cells to mubritinib suggests that use of this inhibitor might be an alternative therapeutic strategy for the management of gastric cancer resistant to FGFR inhibitors owing to EMT.
However, the role of vimentin in WFA-induced toxicity is strongly supported and is reflected in the marked sensitivity of vimentin-expressing cells to the compound when compared to other cancer cells (as evidenced by IC50 values in the nanomolar vs. micromolar range, respectively).
This was particularly apparent in the marked effect on Ser65 phosphorylation in the WB-F344 and WB311 cells, which showed marked sensitivity and resistance with regard to DNA synthesis, respectively.
