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The structure factor analysis also demonstrates a marked sensitivity of the respective diffraction spot intensities to a slight change in both side group position and side group bulkiness.
The results revealed different behaviors and a marked sensitivity of the LaCoste & Romberg D 185 and Scintrex CG-3 M#9310234 gravimeters when subjected to vibrations of a few tens of micrometers, both in the horizontal and vertical directions.
The marked sensitivity of PIK3CA-mutated and/or HER2-overexpressing breast cancer cells to AKTi-1/2 allowed us to examine the functional consequences of Akt blockade in these cells.
However, the role of vimentin in WFA-induced toxicity is strongly supported and is reflected in the marked sensitivity of vimentin-expressing cells to the compound when compared to other cancer cells (as evidenced by IC50 values in the nanomolar vs. micromolar range, respectively).
An example of this strategy is represented by marked sensitivity of MM cells to poly(ADP-ribose) polymerase (PARP) inhibitors triggered by 26S proteasome inhibition.
Despite the marked sensitivity of the medulloblastomas to the epipodophyllotoxins, three early passage cultures were much more resistant to these drugs than the average for the group.
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As regards E. coli, after three hours, a marked sensitivity to treatment has been observed, regardless of the amount of the ozonated oil.
Thus, expression of mre11-H59A conferesistantstont to ETP and CPT, despite marked sensitivity to HU and IR; and expression of mre11-H125N strain conferred resistant to ETP, despite sensitivity to CPT, HU and IR.
Some authors reported vasodilatation at a cerebral level in response to vasopressin, with more marked sensitivity to vasopressin in the circle of Willis [ 2, 73].
Of the cell lines examined, the response of UMCL01-101 most closely resembled that of LCL8664 in that the marked sensitivity to TGF-β1-mediated growth inhibition was rescued in part by treatment with IL-6.
Patients with NBS are characterised by stunted growth, microcephaly, marked sensitivity to ionising radiation, chromosome translocations, and increased incidence of leukaemia and lymphoma.
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