Sentence examples for marked regulation from inspiring English sources

Marked regulation of genes involved in lipid and glucose metabolism and pathways producing NADPH and glycerol-3-phosphate (G3P) was seen during the terminal differentiation, also characterised by diverse stress responses.

Among others, these cases demonstrate that substitutions of the N-glycan core, known to act as switches for cis/ trans-interactions [ 1, 12], and the status/linkage type of sialylation are particularly prone to marked regulation: a result that guides the selection of tools (for example, lectins [ 13]) to monitor these aspects of the glycophenotype under disease conditions.

A marked regulation was also observed in the signaling pathways related to TGF-β (25 genes), Toll-like receptor (19 genes), Fc epsilon RI (18 genes), adipocytokine (13 genes), NOD-like receptor (13 genes), RIG-I-like receptor (12 genes), mTOR (11 genes) and intestinal immune network for IgA production (8 genes) (Additional file 4).

In this paper, timed continuous PNs with piecewise-constant maximal firing speeds are introduced for the marking regulation and sufficient conditions for the existence of a steady state are proposed in forced regime.

The presence of an HS site could be a dynamic feature when it marks regulation triggered by a transcriptional event.

While, 1344 unique genes exhibited a marked up regulation, 1856 genes were significantly down regulated.

While, 1344 unique genes exhibited a marked up regulation, 1856 genes were significantly down regulated in the lungs of infected guinea pigs as compared to the lungs of uninfected animals as depicted by a heat map in Figure 3.

The molecular mechanism of such selective down regulation of MMP-9 mRNA might be the consequence, at least in part, of the marked down regulation of nucleolin.

We also show that FGF signaling is sufficient for MKP1 and DUSP5 expression; treatment of animal cap explants with FGF proteins leads to marked up regulation of both genes (Figure 3C).

In cases of tuberculous meningitis, marked down regulation of protein expression was seen in contrast to the normal cortex.

Characteristically, majority of the genes related to MAPK, Wnt and Calcium signaling pathways exhibited a marked down regulation (Table 3).