A complete physicochemical characterization including an isothermal titration calorimetry (ITC) study revealed that the use of poloxamer led to nanocapsules with a marked reduction in the number of protein-binding sites.
Histological evidence suggested a marked reduction in the number of infiltrating inflammatory cells when particles were delivered within Dex-PA nanofiber gels, and very little inflammation was observed at either 3 days or 21 days post-implantation.
And the Pi itself is very much an academic project - most of its members are, or were, Cambridge University academics who noted a "marked reduction" in the number of students applying to read computer science from the mid-1990s.
Ekweozor (1989) reported that frequent spillage of crude oil and its products in creeks and rivers may have resulted in a marked reduction in the number of both freshwater and marine organisms.
RNAi-mediated knockdown of endogenous DISC1 resulted in a marked reduction in the number of cells expressing a primary cilium.
Population genetic theory posits that the first genetic signature of a population crash should be a marked reduction in the number of alleles per locus (i.e., allelic richness) as rare alleles are lost via genetic drift [5].
However, neurons growing on top of TSP-1 KO astrocytes exhibited a striking increase in the number of filopodium spines and a marked reduction in the number of stubby spines (Figure 7B and C).
Hippocampal neurons maintained in DS astrocyte CM showed a marked reduction in the number of spines compared to neurons maintained in NL astrocyte CM (NL CM: 6.2±0.5 spines per 50 µm of dendrite; DS CM: 3.6±0.3 spines per 50 µm of dendrite)(Figure 2B).
Immunofluorescence studies performed using GLAST (radial glial cells) and TuJ1 (post-mitotic neurons) antibodies revealed a marked reduction in the number of neurogenic divisions in cells from the Ptc1Lox/Lox NestinCre neocortex compared to the wild type littermates (Fig. 2C, 2D, 2G).
Against the backdrop of very low transmission in this study, the differences seen compared to the earlier trials conducted in the same villages are probably attributable to a marked reduction in the number of transmission (re-infection) cases rather than to changes in drug sensitivity.
A marked reduction in the number of osteoclasts and osteoblasts in affected bone were consistently observed.
