Sentence examples for marked production of from inspiring English sources

In murine models of human rheumatoid arthritis, γδ T cells have been reported to be pathogenic through marked production of IL-17 [14].

Chronic inflammation is a common observation during cancer progression and is associated with marked production of cytokines that could further aggravate tumour progression.

We have previously shown that anti-CD3/CD28-induced activation of purified human γδ T cells results in marked production of IFNγ, with little or no production of IL-17 [21].

This is achieved by marked production of anti-inflammatory mediators (DISIP, IL1RN, IL15RA, TNFAIP3, NFKBIA and NFKBIE) and downregulation of proinflammatory genes during the second stage of the disease (TNFRSF8, CXCL5, C7, ITGB1BP1).

The marked production of IFN-γ, IL-4, IL-17 and IL-10 by activated CD4+ T cells reflects the heterogeneous nature of cells in this population, i.e. T helper type 1 (Th2), Th17 Th17 and regulatory T cells (Treg).

Consistent with the increased sPLA2 secretion by IL-1β-stimulated SF cells, marked production of MMPs (MMP-1, MMP-2, MMP-3 and MMP-9) was also observed at 24 hours.

This finding suggests that down-regulation of antigen-presenting mechanisms occurs which possibly is caused by marked local production of iNOS and NO by infiltrating macrophages.

However, if we assume a marked endogenous production of progesterone during CPB, the net result could be a rise in progesterone even though adsorption to the circuit had occurred.

The findings that the presence of M. bovis antigens in necrotic foci is associated with marked local production of iNOS and NT strongly suggest that in the development of these joint lesions nitritative injury is involved as in necrotizing lung lesions of M. bovis- infected calves.

Interestingly, we did not find any marked leukotoxin-induced production of IL-1 β at the mRNA level that could explain this increase in IL-1 β protein.

A clue may lie in earlier experiments, in which the same researchers observed a marked increase in production of K- ras (an oncogene associated with prostate cancers) in arsenic-transformed cells.