Sentence examples for marked phosphorylation of from inspiring English sources

However, the S56A/S180A mutant that was able to survive peroxide treatment also did not exhibit marked phosphorylation of Akt.

We also detected marked phosphorylation of ERK1/2 and c-Myc expression in 10% FBS-added cultures.

The mTOR(L2209V) mutant was found not only to mediate marked phosphorylation of p70S6K but also to possess transforming ability when expressed in mouse 3T3 fibroblasts.

When added after 16 h, marked phosphorylation of Chk1 and H2AX occurred within 2 h consistent with the hypothesis that replication forks become more Chk1 dependent over time.

Short-term in vitro studies with bovine myogenic cells have demonstrated greater INSR and IRS1 protein, marked phosphorylation of IRS1, as well as greater protein of downstream effectors (phosphoinositide-3-kinase,SLC2A4) within minutes of insulin stimulation [ 45, 46].

After a 24 h incubation of MDA-MB-231 cells with 50 nmol/L gemcitabine, there was marked phosphorylation of Chk1 at both ser345 and ser296 which suggests the presence of DNA damage, probably single-stranded regions in DNA as there was negligible phosphorylation either H2AX or DNA-protein kinase which should appear if there are DNA double-strand breaks (DSB).

DNA double-strand breaks are marked by phosphorylation of H2AX at serine 139 (γ-H2AX).

To explore the potential interaction between Thy-1 and SFK activation by TNF-α in MEFs, SFK activity was examined by immunoblots with an antibody specific for the active form of SFK which is marked by phosphorylation of tyrosine 416 in c-Src as well as the equivalent sites in other SFKs.

While the detailed mechanism by which c-Myc regulates chondrocyte proliferation remains unclear, we show that transcription initiation by RNA PolII, as marked by phosphorylation of its CTD, is strongly upregulated in proliferating chondrocytes where c-Myc is expressed (Fig. 6B, Fig. S3).

Significant muscle and body weight loss were observed, as was marked the phosphorylation of ERK, a mitogen activated protein kinase.

Ionising radiation stimulated AMPKT172 phosphorylation and activity, marked by phosphorylation of its direct target acetylCoA carboxylase (ACC), in response to 8 Gy IR.