Sentence examples for marked phenotypic changes from inspiring English sources

In response to elevated IOP in human POAG and in experimental glaucoma, astrocytes undergo marked phenotypic changes [5].

We find here that NS cells self-renew normally in the absence of Dicer but fail to differentiate due to marked phenotypic changes that block their ability to fully execute a differentiation programme.

All three asMOs successfully inhibited translation of the targeted protein, and two of the three asMOs resulted in marked phenotypic changes.

Despite the marked phenotypic changes in the intestine related to occurrence of NEC, no marked changes in intestinal DNA methylation was found, at least not within the first days of neonatal life.

This marked phenotypic change was significantly associated with increased methylation of six cytosine guanine sites in a retrotransposon upstream of the transcription start site of the Agouti gene.

Indeed, we have recently shown that CNTF-activated astrocytes display marked phenotypic and molecular changes associated with an improved handling of extracellular glutamate in the rat striatum [12].

Many mutants show marked phenotypic deviations from corresponding wild types, but mutations in most genes lead to more subtle changes in knock-out or antisense plants, with the lack of observable phenotypic deviations being the rule rather than the exception (see e.g. [ 28, 29]).

These small-size fishes exhibit marked phenotypic diversity that hinders their discrimination.

Our results indicate marked phenotypic variation across all traits measured, including comparisons of young and older Gene Mine mice.

Heterophyllous aquatic plants show marked phenotypic plasticity.

Macrophages exhibit marked phenotypic heterogeneity [5].