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We found that silencing of GIPC resulted in an increase in the percentage of apoptotic cells in HUVEC and also had marked morphological effects on the EC, including cytoplasmic shrinkage and cell retraction (Figure 2b, Figure S2a).
Although marked morphological effects were observed in irreversibly growth-inhibited cells, the cells remained attached to the substratum and showed no evidence of nuclear pyknosis or apoptosis.
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However, at the stage of flowering, elp6 mop2 RP40p::PIN1 still exhibits marked morphological defects.
We and others have shown that the neonatal uterus is prone to DES-mediated teratogenic effects, exhibiting marked morphological and gene expression changes shortly after DES exposure (Huang et al., 2005; Ma et al., 1998; Miller et al., 1998; Yin et al., 2008).
The CCF-induced morphological changes in U87 cell death are shown in Figure 2. Compared with controls, these results demonstrated that there were marked morphological changes in U251 glioblastoma cells when treated with CCF, and these effects were dose- and time-dependent.
All insects, including Drosophila, undergo marked morphological changes during their development to adult stage known as metamorphosis, which is an excellent parameter to detect physiological effects following environmental fluctuation.
Both treatment groups showed marked morphological changes in glia within the OVLT and SSO/SFO.
However, marked morphological differences in shapes exist, depending on virus type.
In addition, compound 13 displayed marked morphological activity (rounding up) at nanomolar concentrations on endothelial cells (EA.hy 926 cells), which is indicative of potential antivascular activity.
Lateral plain radiograph shows marked morphological alteration of the heel with irregular lytic areas and concomitant PF thickening (double-head arrow) due to spreading of the infection (a).
However, WJMSCs did not show marked morphological changes on treatment with pro-inflammatory cytokines consistently (Figure 1A).
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