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The central role of hepcidin in iron homeostasis, coupled to its marked modulation in HepG2 cells undergoing ER stress, prompted us to focus on this molecule.
Heat stress caused a marked modulation in H2S leaf content, manifested by a significant increase after 1, 4 and 8 h of exposure to 42°C compared with control samples.
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However, both agents induced marked modulations in the levels of Bcl-2– and Bax-positive cells when tested either individually or in a binary mixture.
DNA microarray studies using T. rubrum and synthetic inhibitors of FAS (PHS11A and PHS11B) have shown marked transcriptional modulation of several genes such as FAS1 and FAS2, ERG6 (a gene involved in ergosterol metabolism), and multidrug resistance genes [ 13, 14].
Indeed, it has recently been shown that the degree of movement-related modulation of high-frequency oscillations by beta negatively correlates with bradykinesia/rigidity scores and that in the on-medication state the high-frequency oscillations are released from lower-frequency coupling and demonstrate marked amplitude modulation related to movement.
A study on BOLD response during migraine visual aura revealed marked suppression to light modulation in visual cortex that has spread with a rate corresponding to progression of hemifield scintillations described by a subject [ 89].
Multisymbol codes in which messages are first mapped into sequences of symbols (source coding) and then systematically mapped into message marks (modulation) reduce computational complexities.
We carried out electrophysiological recordings using hippocampal slices prepared from adult sandy mice and found marked abnormalities in monoaminergic modulations at the mossy fiber-CA3 synapse.
Furthermore, as marked in the lower zoom-in panel for negative V BG, it is possible to identify fine modulations of the potential inside the heavily-doped slit.
The molecular pathways triggered in these cells induce marked changes in gene expression causing modulation of their cellular phenotypes resulting in proliferation, differentiation or migration.
Although we were cautious to ensure that any exposure-associated alterations in DNA methylation were not merely due to changes in the ratios of blood cells by including blood cell proportions as key covariates in all of our models (explained in Methods)—we lack the ability to link these epigenetic marks to any appreciable modulation in gene expression in these blood cells.
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