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In the hippocampus (Fig. 1c), there was marked involvement of the granule cells of the dentate gyrus, which in some cases was accompanied by inclusions in neurons of the CA regions.
In the corticobasal degeneration group, grey matter loss was relatively symmetric and most marked in the dorsolateral frontal cortex, insula, superior temporal cortex, anterior cingulate and caudate, with less marked involvement of precuneus and inferior parietal cortex; white matter loss was most marked in the region of the superior longitudinal fasciculus and inferior longitudinal fasciculus.
In the MAPT mutation group, grey matter loss was relatively symmetric between the cerebral hemispheres and most marked in medial and anterior inferior temporal cortex with less marked involvement of orbitofrontal cortex and insula; localized white matter loss was evident in the region of the anterior inferior longitudinal fasciculus and fornix.
NTM tend to cause thin-walled cavities with less surrounding parenchymal infiltrate, have less bronchogenic but more contiguous spread of disease, and produce more marked involvement of pleura over the involved areas of the lungs [ 43].
TDP-A was associated with asymmetric atrophy with a frontal emphasis but extending rather diffusely within the more affected hemisphere to involve the parietal lobe and with marked involvement of the cingulate.
In the TDP-C group, there was asymmetric grey matter loss predominantly involving the temporal poles and anterior inferior temporal cortex with less marked involvement of orbitofrontal cortex, insula and anterior cingulate; white matter loss was evident predominantly in the region of the inferior longitudinal fasciculus, uncinate fasciculus and fornix.
Similar(46)
Based on investigations, the patient showed pancytopenia, hepatosplenomegaly, bone marrow involvement and marked colonic involvement.
It points very strongly to marked Chinese involvement".
All patients have marked oral involvement, with devastating alterations in the soft and hard tissues in all cases.
Pulsed doses of methylprednisolone were restricted to those with disease progression and marked lung involvement.
Previous autopsy reports of INAD and ANAD have also described marked cortical involvement of LBs [ 1, 8].
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