Sentence examples for marked instability of from inspiring English sources

Since production of the PS-1 protein and the overall processing seem un-impaired, we interpret the loss of 23 kDa CTF to indicate marked instability of that processed fragment of PS-1 in cells deficient in HPRT expression.

We now provide evidence that HPRT deficiency produces aberrations in both the canonical Wnt/β-catenin signaling as reflected by elevated levels of cytosolic phosphorylated β-catenin, markedly impaired nuclear transport of β-catenin for faithful gene regulatory function and marked instability of the 23 kDa C-terminal fragment (CTF) of PS-1.

If carotid chemoreceptors did cause matching, the simplest consequence of their ablation should be marked instability of both blood gases and breathing on a breath-by-breath basis, both at rest and during exercise.

Second, the marked instability of samples 14 and 15.

The CD unfolding data highlight the marked instability of the coiled-coil structure to decreases in pH.

Similarly, more patients in the T2DM group suffered from generalized periodontitis and visible mobility or marked instability of teeth (scores 3 and 4).

In 45 elbows that had been graded as Larsen grade 4 preoperatively, 32 elbows remained at grade 4 and 13 elbows progressed to Larsen grade 5. Assessment of clinical mediolateral joint stability showed minimal instability (0 5°) in 59 elbows, moderate instability (6 10°) in 3 elbows, and marked instability (> 10°) in 2 elbows.

Price gave her a diagnosis of borderline personality disorder, an illness marked by instability of mood and self-image.

Poor dentition, a new phenotype that may be aging-related, appeared in bitransgenic mice with Dox treatment d20-80 (N = 15) or d20-160 (N = 2), marked by instability of the incisors with resulting malocclusion and overgrowth (Fig. 3alll, 5/17 mice, P = 0.05).

In Dnmt1-deficient mice, a similar phenotype was observed including genomic hypomethylation, increased lymphomagenesis, and marked genomic instability, particularly trisomy of chromosome 15 (Gaudet et al. 2003).

Northern white rhinos were found in the wild in countries marked by instability, including the Democratic Republic of Congo, the Central African Republic and Sudan.