Sentence examples for marked gain of from inspiring English sources

The RA-mediated downregulation of prion modifier genes led to a marked gain of susceptibility, suggesting that the rate of prion propagation is associated with transcriptional regulation of gene candidates.

Life expectancies had grown, education reforms had produced marked gains in functioning and — of particular interest to Costa — a mouse model of the disorder had recently been developed, opening the door to experimentation.

This work has integrated microarray-based global gene expression and epigenomic profiling of prostate cancer cells and their normal counterparts and found that transcriptional activating marks (gain of H3K4me3 or loss of H3K27me3) and silencing marks (gain of H3K27me3 or loss of H3K4me3) were tightly associated with upregulated and downregulated genes in prostate cancer cells, respectively.

The revised total for 1999 marked a gain of 4.2percentt from $205.2 billion spent abroad in 1998.

Even when induced continuously, Snail-1 binds only transiently (6 48 hr) to its target repressed promoters with loss of activation marks and gain of chromatin silencing marks being detectable after Snail-1 itself is no longer immunoprecipitated from its target promoters.

Thus successful retrotransposition events are marked by a gain of kanamycin resistance which allows for selection of rare intron integration events.

An improved economic outlook and lower business costs pushed up Louisiana's rank from No. 40 to No. 29, marking the biggest gain of any state.

A comprehensive list of the families marked as Gain or Loss.

Effect on weight, compared to other drugs, some of which cause marked weight gain.

This phenotype coincides with the occurrence of aberrant chromatin modifications at promoters of misregulated genes: a loss of active histone marks (H3K4me), a gain of repressive histone marks (H3K9me, H3K27me) and, nota bene, a gradual accumulation of CpG methylation (Cortazar et al. 2011).

Specifically in cancer, a global loss of H4K16ac is seen alongside loss of the transcriptionally active mark H3K4me3 and gain of the transcriptionally repressive marks H3K9me and H3K27me [ 38].