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We show that RNAi-mediated ablation of various proteins identified in the trypanosome flagellar proteome leads to a rapid and marked failure of cytokinesis in bloodstream-form (but not procyclic insect-form) trypanosomes, suggesting that impairment of flagellar function may provide a method of disease control.
It is also seeking views on "whether Local Transport Authorities should take measures to encourage competition, including whether franchising (where operators would compete for the right to provide services) might be required in cases where there has been a particularly marked failure of competition".
They charged that "racial disparities" in admission to the city's select high schools resulted "in large part from admissions policies that rely too heavily or even exclusively on standardized tests" and on a "marked failure to provide African Americans and Latinos with opportunities to learn the material or otherwise prepare to meet the admissions standards".
Third, in these patients there was also a marked failure to alter the apparent SID to achieve a degree of metabolic compensation (Fig. 3).
During severe sepsis occurs a marked failure of neutrophil migration into the infectious focus, which is associated with dissemination of infection resulting in high mortality.
We found moderately decreased viability in Atg7−/− B cells following stimulation, but a marked failure of differentiation into plasma cells, associated with reduced secretion of IgM.
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Nunez's final endeavor could fundamentally change the Legislature -- and correct one of his most marked failures.
Radio-resistant hypoxic tumor cells are significant contributors to the locoregional recurrences and distant metastases that mark failure of radiotherapy.
A few miles away in Chapel Hill, a task force has recommended that the University of North Carolina strengthen its honor code by publishing a kind of police blotter of cheating incidents -- no names -- in the daily campus newspaper, lowering the standard of proof for cheating and adopting a grade of XF to mark failure due to cheating.
Panama marked a failure of Latin diplomacy, too.
Vivaldi's impresarial forays became increasingly marked by failure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com