Sentence examples for marked exacerbation of from inspiring English sources

She now requires a stick for walking, but her symptoms have remained generally stable during adult life, though she experiences marked exacerbation of weakness during viral illness.

In summary, this indicates a marked exacerbation of AIA by depletion of CD25-expressing cells.

In contrast, mercury-exposed rats had a marked exacerbation of the histopathological severity of the arthritis, and the infiltration was predominantly neutrophilic.

Furthermore, hIL-32β-transduced CD4+ T cells showed marked exacerbation of collagen-induced arthritis, an effect that was, in part, cancelled by TNFα blockade.

A more recent study performed in rats demonstrated that PPIs lead to a marked exacerbation of small intestinal ulceration induced by NSAIDs, which was transferable to germ-free mice via microbiota isolated from the PPI-treated rats.

This study provides novel evidence that FGF21 deficiency causes a marked exacerbation of atherosclerosis and increased mortality of apoE−/− mice, suggesting that FGF21 is a physiological protector against vascular diseases.

The natural history of the disease is marked by exacerbations that affect the prognosis of patients with COPD [ 2].

Indeed, acute kidney injury, marked sodium retention and exacerbation of systemic hypertension have been reported with the use of COX-2 selective drugs in humans [ 2, 3].

Bowen et al found that 48% of GPs were not confident in diagnosing CFS/ME in adults and 51% could not identify 3 key clinical features (fatigue, symptom exacerbation on over-exertion and marked fluctuation of symptoms) [ 17].

The natural history of the disease is marked by the occurrence of exacerbations affecting the prognosis of patients [ 2].

What was surprising was the marked reduction in exacerbation rate as defined by the need for antibiotic therapy.