Sentence examples for marked efficacy from inspiring English sources

The polyamine-inhibitory regimen difluoromethylornithine (DFMO +sulindac has marked efficacy in preventing metachronous colorectal adenomas.

A phase I trial revealed that CH5424802 had marked efficacy and was well tolerated in patients with ALK rearrangement-positive NSCLC.

Marked efficacy of crizotinib in ALK-positive NSCLC was seen early in clinical development in an expanded cohort of a phase I study and a single-arm phase II study [ 1, 2].

Despite warfarin's marked efficacy, not all eligible patients receive it for stroke prevention in AF [ 5].

Despite warfarin's marked efficacy, not all eligible patients receive it for stroke prevention in AF.

ACE is also expected to provide economic benefits owing to its better tolerability and marked efficacy [ 11].

87, 88 A phase I trial revealed marked therapeutic efficacy of crizotinib in patients with NSCLC positive for EML4-ALK (Table 2), with an overall response rate of 60.8% and a disease control rate of up to 90%.

We surmise that the VEGF signal had a dual effect on SS tumor growth, namely, on proliferation in an autocrine loop and on host angiogenesis in a paracrine manner; thus, VEGF-targeted therapy showed marked antitumor efficacy in SS.

To assess whether simultaneous blockage of VEGF and CXCL12/CXCR4 signaling had any marked antitumor efficacy in SS, we validated the antitumor effects of VEGF signal inhibitors in combination with CXCL12/CXCR4 signal inhibitors on two SS cells.

A high proportion of subjects (60%100%%) judged the effect of FRC to be medium, marked, or very marked for all efficacy parameters.

Notably, administration of an orally-available inhibitor of MEK1/2 elicited marked anti-tumor efficacy in mouse xenograft models of colon cancer and metastatic melanoma [ 19, 20].