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Extensive mononuclear cell infiltration and a marked disorder of the retinal outer nuclear layer (EAU score 3+) was observed by day 14 or 21 in mice receiving 50 or 100 µg IRBP peptide and 0.5 1 µg PTX.
As far as the cerebral cortex is concerned, evidence has been recently provided for a marked disorder of its connectivity involving primarily, although not exclusively, intrahemispheric connections [see 12] [16].
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In line with previous studies (Craig et al., 2000), onset of psychosis was defined as the presence for 7 days or more of one of the following psychotic symptoms: delusions; hallucinations; marked thought disorder; marked psychomotor disorder; and bizarre, grossly inappropriate and/or disorganised behaviour with a marked deterioration in function.
The clinical presentation was characterized by mild tremors and myoclonus, progressing to a marked cognitive disorder, including spatial disorientation but without anxiety, aggressiveness or loss of appetite.
The succeeding period was marked by disorder and internal strife.
Alzheimer's is an irreversible brain disease that destroys memory, and it is one form of dementia, a disorder marked by the loss of mental functions.
Alzheimer's disease (AD) is the most common neurodegenerative disorder marked by progressive loss of memory and impairment of cognitive ability.
Out of a total 799,153 residues in the PDB dataset, 5.1% (40,455) of the residues were marked as disordered.
Hyaline protoplasmic astrocytopathy is a rare disorder marked by an accumulation of protein material in the cytoplasm of astrocytic cells, mostly in the cortex.
The disorder is marked by lack of focus and excitability.
Ketosis, metabolic disorder marked by high levels of ketones in the tissues and body fluids, including blood and urine.
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