Sentence examples for marked difficulty from inspiring English sources

If we plot (varphi_{omega}) it will resemble the Euclidean Bessel-kind covariance functions; only there is a marked difficulty in dealing with the growth at infinity of these functions, which accounts for some (not all, of course) of the many difficulties Harish-Chandra and Helgason had to overcome in developing harmonic analysis on (mathbb{D}).

First, bipolar disorder is often associated with marked difficulty in establishing and maintaining relationships [ 39- 41].

MH's most pronounced aphasic symptom, both initially and residually, was a marked difficulty in confrontation naming in both languages.

RA is an 87-year-old male with marked difficulty in walking due to some degenerative joint disease involving neck and spine.

Bipolar disorder is characterized by marked difficulty in regulating the pursuit of goals (Johnson, 2005), with the onset of manic and depressive episodes linked to the attainment and failure to obtain goals, respectively (Johnson et al., 2008).

Given the predominance of rodent models of human disease and the marked difficulty in performing transplantation experiments in these models, it remains unknown whether Tsc1 or Tsc2 mutant cells can produce the focal brain hamartomas that are almost universally seen in patients with TSC.

A testifying psychiatrist reported that Edwards could understand the charges against him, but he was "unable to cooperate with his attorney in his defense because of his schizophrenic illness"; "[h]is delusions and his marked difficulties in thinking make it impossible for him to cooperate with his attorney". Id., at 164a.

But his tenure at the helm of Johns Hopkins is remembered by many just as much for its marked difficulties.

According to its definitions, which can be found here, the category includes post-traumatic stress syndrome and phobias or compulsions that result in "marked difficulties" with working or living in society, or "complete inability to function independently outside the area of one's home".

Bibliotherapy is suitable for people with moderate depression, but is unsuitable for individuals with severe depression [ 47] because of marked difficulties in concentrating and cognitive impairment, and a greater suicide risk [ 48].

A totally displaced fracture is one of the most difficult fractures to manage because of marked swelling, difficulty in reduction and maintaining the reduction until healing takes place.