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"marked difference in" is a correct and usable phrase in written English.
It is used to describe an obvious, noticeable change between two things. For example, "There was a marked difference in their attitudes toward the new policy."
Exact(60)
There was marked difference in some characteristics across cities. (Additional File 3, Table S1).
In addition, we did not find marked difference in these associations between developing and developed countries.
This marked difference in survival rates makes the need for reliable screening tests obvious.
A marked difference in hydrolysis rate at different impeller speeds was found.
There is a marked difference in the results given by different techniques.
There was, however, a marked difference in the prevalence of the infection in different areas.
Again, there was a marked difference in lung metastases.
In addition, there was a marked difference in lung metastases.
The findings also show a marked difference in the way male and female CEOs were recruited.
The study also shows a marked difference in the way the genders are treated.
However, Rubinsohn said there was a marked difference in responses from agents around the country.
More suggestions(1)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com