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DA+ group showed marked deposition of amyloid occupying large area of islets.
Safranin O staining revealed marked deposition of glycosaminoglycans in the matrix (Fig. 2d).
Older mdx females present extensive fibrosis, increase of the permeability of the sarcolemma, and marked deposition of extracellular matrix components compared to mdx males [ 31].
Examination of the midbrain showed very severe loss of pigmented neurons in the substantia nigra accompanied by gliosis, macrophage infiltration and marked deposition of Perl's positive pigment.
Histopathologic findings in these animals included marked deposition of immune complexes containing C3 in glomerular subendothelial, mesangial and subepithelial locations and glomerular inflammation with infiltrated neutrophils and macrophages [ 21].
This effect may explain the worst outcome of female mdx mice, which present extensive fibrosis, increased permeability of the sarcolemma, and marked deposition of extracellular matrix components, once they had been suffering a prolonged action of estrogens [ 33].
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However, prominent spongiform changes and marked depositions of PrPsc in the brain confirmed the clinical suspicion of an SE.
Among these, the histone methyltransferase EZH2 is a fundamental negative regulator of myogenic precursor differentiation by repressing the expression of myogenic genes through the H3K27me3 mark deposition on the promoters of myogenic genes [ 22, 28].
Septic animals showed marked renal deposition of TCC.
These falling stage systems tract deposits are separated from latest Pliocene/early Pleistocene lowstand shelf edge deltaic deposits by a subaerial unconformity marking the deposition of sequence four (Facies D3).
Although plasma levels of TCC declined over study period, in septic animals marked renal depositions of TCC indicated complement activation.
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