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DA+ group showed marked deposition of amyloid occupying large area of islets.
Safranin O staining revealed marked deposition of glycosaminoglycans in the matrix (Fig. 2d).
Older mdx females present extensive fibrosis, increase of the permeability of the sarcolemma, and marked deposition of extracellular matrix components compared to mdx males [ 31].
Examination of the midbrain showed very severe loss of pigmented neurons in the substantia nigra accompanied by gliosis, macrophage infiltration and marked deposition of Perl's positive pigment.
Histopathologic findings in these animals included marked deposition of immune complexes containing C3 in glomerular subendothelial, mesangial and subepithelial locations and glomerular inflammation with infiltrated neutrophils and macrophages [ 21].
This effect may explain the worst outcome of female mdx mice, which present extensive fibrosis, increased permeability of the sarcolemma, and marked deposition of extracellular matrix components, once they had been suffering a prolonged action of estrogens [ 33].
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However, prominent spongiform changes and marked depositions of PrPsc in the brain confirmed the clinical suspicion of an SE.
In addition to the micro-fossil evidence, abrupt termination of deposition of clayey lacustrine sediments, marked by deposition of fluvial and prodeltaic sediments in the southern Kathmandu basin, clearly indicates a lowering of lake-water level.
Kidney biopsy often shows marked glomerular deposition with frequent obliteration of capillary lumina and little to no extra-glomerular deposition [ 7, 52, 54, 55].
Septic animals showed marked renal deposition of TCC.
LS- G6pc−/− mice had marked glycogen deposition in hepatocytes (Fig. 2A).
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