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In addition to the Wnt signaling aberration, we found that expression of presenilin-1 shows severely aberrant expression in HPRT-deficient SH-SY5Y cells, reflected by marked deficiency of the 23 kDa C-terminal fragment of presenilin-1 in knockdown cells.
In addition a marked deficiency of NK cells in the spleen was noted.
Excessive secretion of the acid causes gastric ulcers; a marked deficiency of it impairs the digestive process and is sometimes the primary cause of deficiency anemias.
We chose this area because of its marked deficiency of preventive and prophylactic health measures.
Failure to fluoresce after 10-min of incubation suggests a total or marked deficiency of G6PD.
Demonstration of marked deficiency of α-galactosidase A is the definitive method for the diagnosis of hemizygous males [ 3].
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Lymphoblasts from choroideremia subjects showed a marked deficiency in the activity of component A, but not component B, of Rab GG transferase.
In this genetically modified animal model we could demonstrate a marked deficiency in the number of new neurons generated in the hippocampi of p50−/− mice [ 86].
Here we report that a marked deficiency in total copper, of ~50%, occurred in the LV myocardium of diabetic rats with DCM and, strikingly, that there was full restoration of copper to control levels following treatment with the Cu (II -selective chelator, TETA, [ 8, 48].
This lack of a marked deficiency phenotype implies that the GCR2 gene family may not be critical for plant development, but leaves open the possibility that these mutants may only exhibit phenotypes under certain conditions (e.g. under biotic and abiotic stresses).
In the third project, we generated C57BL/6-Cpa3-Cre C57BL/6-Cpa3-Cre C57BL/6-Cpa3-Crethey are severely deficient in mast cells and also have a marked deficiency in basophils, whereas the numices of the mand other hematopoietic cell populationshowedined exhibithatthey or no chareeseverely
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