Sentence examples for marked defects in from inspiring English sources
Our findings indicate that abdominal sepsis results in marked defects in the ability to express important innate genes.
Consistent with this idea, Pax7−/− satellite cells are specified but exhibit marked defects in their ability to both proliferate and differentiate [15], [17], [18].
Taken together, these results demonstrate that ectopic HH signaling activity in proximal ureteric cells causes renal hypoplasia, characterized by marked defects in the formation of nephrogenic structures, reduced ureteric branching and a qualitative defect in early stage ureteric branch tips.
Apropos of this model, it has been shown that disruption of Notch-Delta signaling in the developing zebrafish retina results in marked defects in the planar patterning of photoreceptors such that the regular mosaic pattern is lost and photoreceptors of the same type show a highly irregular and partially clumped distribution [64].
The knockdown of pancTbc1d22a and pancBag6 did not cause marked defects in preimplantation development.
Furthermore, a naturally occurring Cacna2d4 mutant mouse displayed retinal degeneration with marked defects in the synaptic layer.
Consistent with the temperature-dependent cell morphology changes in the pmt mutants, both pmt1A and pmt4A strains displayed a marked defect in growth at elevated temperatures (Figure 5).
In support of this idea, contraction of circumferential actin belt in lining epithelial cells is critical for closure of the neural tube [31], and Syt-null mouse embryos have a marked defect in neural tube closure (Kimura, 2009).
Therefore, the marked defect in ciliogenesis observed in 1/2 KO cells is likely to result from the inability of these cells to respond to signals that inhibit cell proliferation.
The defects in Vav1-deficient thymic development, including a marked defect in DN3-DN4 transition, were completely reversed by Cbl inactivation, accompanied by enhanced phosphorylation of PLC-γ1 and ERKs in response to pre-TCR/TCR cross-linking of Vav1-/-Cbl-/ DP thymocytes.
Anaemia is microcytic and characterised by a marked defect in iron supply for erythropoiesis [ 4].
