Sentence examples for marked defect from inspiring English sources

Consistent with the temperature-dependent cell morphology changes in the pmt mutants, both pmt1A and pmt4A strains displayed a marked defect in growth at elevated temperatures (Figure 5).

In support of this idea, contraction of circumferential actin belt in lining epithelial cells is critical for closure of the neural tube [31], and Syt-null mouse embryos have a marked defect in neural tube closure (Kimura, 2009).

Therefore, the marked defect in ciliogenesis observed in 1/2 KO cells is likely to result from the inability of these cells to respond to signals that inhibit cell proliferation.

The defects in Vav1-deficient thymic development, including a marked defect in DN3-DN4 transition, were completely reversed by Cbl inactivation, accompanied by enhanced phosphorylation of PLC-γ1 and ERKs in response to pre-TCR/TCR cross-linking of Vav1-/-Cbl-/ DP thymocytes.

Anaemia is microcytic and characterised by a marked defect in iron supply for erythropoiesis [ 4].

As described earlier, a marked defect was observed in the class-switched isotypes in the ICOS /– mice (Fig. 1).

The NF-κB signaling pathway was suspected to be crucially involved in the development of naturally occurring Treg cells, because mice lacking molecules of proximal TCR signaling leading to NF-κB activation, such as PCKθ, Bcl10, or CARMA1, show marked defects in the thymic generation of Treg cells [48], [49], [50], [51].

However, the axonal arborizations of mutant PNs in the protocerebrum manifested marked defects.

Evidence has emerged that TLR4 defective mice do not develop LV dysfunction after LPS stimulation whereas wild type mice developed marked defects in LV contraction and relaxation [ 25].

Thus, NON mice have a marked secretory defect, which is corrected to a significant degree by amiloride derivatives.

Moreover, we observed that prometaphase chromosomes isolated from two-cell stage embryos show in 20% of cells (7/36) a marked cohesion defect at the centromeres.