Sentence examples for marked decrease in the expression of from inspiring English sources
Histologically, marked changes were noticed in testes of PTU-treated mice; immunohistochemical and western blot analyses of testes in treated mice also revealed marked decrease in the expression of THRα1 at both age groups.
Moreover, we have recently reported that downregulating galectin-1 expression in Hs683 human glioma cells through targeted siRNA provokes a marked decrease in the expression of the brain expressed X-linked gene (BEX2), a feature which confers increased survival in Hs683 orthotopic xenograft-bearing mice.
The increased miRNA activity observed is indeed reflected in a marked decrease in the expression of these target genes.
We did not study the expression of TLR9 but found that MSC induced a marked decrease in the expression of TLR2 which might explain, at least in part, the enhanced macrophage susceptibility to T. cruzi infection.
Over-expression of heparanase in breast carcinoma cells (MDA-MB-231) was associated with a marked decrease in the expression of MMP family members, yielding a mirror image of the results obtained with the Hpse-KO mice.
Comparison of 2D gels revealed that in the absence of inflammatory stimulus CF cells exhibit a marked decrease in the expression of TRX-1, PRDX-1 and 6, catalase and GST-pi, but a marked increase in SOD2 compared with normal matched cell pairs (Table 1).
Firstly, crypt proliferation was suppressed such that there was a marked reduction in the expression of the mitotic marker phospho-histone H3 and a significant decrease in the ability to pulse-label crypt progenitor cells with BrdU (Fig 4A).
HIF1-deficient T cells display a marked reduction in the expression of IL-17 and Th17-signature genes.
KO mice also show marked reduction in the expression of enzymes involved in oxidative phosphorylation.
SOD1 expression was consistently elevated in trisomy amniocytes and NES showed marked decrease in expression.
Further, immunohistochemistry studies establish marked decreases in AKAP12 expression in experimentally-injured vessels of mice as well as atheromatous lesions in humans.
