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"marked changes" is a correct and usable phrase in written English.
It is typically used to refer to significant or drastic changes. For example, "The new policy has brought about marked changes in the company."
Exact(58)
Chronic depression produces marked changes.
The rewritten table above has two marked changes.
Since the 1950s, however, there have been marked changes.
On the nights that included spicy meals, there were marked changes in the subjects' sleep patterns.
At any rate, nothing is producing any marked changes so far.
Even achieving 75% 'good' status will require marked changes in land use and water infrastructure..
When writer arrived in China last summer after an absence of less than 2 years, he found marked changes.
When thermal changes are considered, marked changes in the maximum strain are observed.
Over the course of the study period, marked changes in fish community structure were observed.
Upon heating, the properties of any polymer undergo marked changes at certain temperatures.
Any new headaches or marked changes in headaches should be evaluated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com