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However, lpr mice showed a marked attenuation in the expression of GFAP at 3 (p = 0.003) and 14 (p = 0.012) days post-SCI compared with Wt mice as determined by Western blot analysis (Fig. 5d).
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After matching, there was marked attenuation in the standardised differences for all baseline characteristics.
Initial analysis of the germ line in Sirt1 deficient mice has shown marked attenuation in development of the testis, and elevated numbers of abnormal sperm in adult male mice [18].
Interestingly, in contrast to WT mice, STAT1−/− mice had marked attenuation in systemic levels of IL-6, IL-10 and IL-12 (Figure 3) suggesting endogenous IFN are required for maximal innate immune activation and cytokine production during inhalational anthrax.
The activity recorded from the first site (green circle, Fig. 5B) showed marked attenuation of the AEP during SV, as well as attenuation of HGB ERBP.
The absorption spectrum of the isolated molybdenum domain of the human C207S mutant displayed marked attenuation of the peak at 350 nm and a lesser decrease in absorbance from 450-600 nm as compared with the native human molybdenum domain.
In fact, the latter seven mutants showed very marked attenuation with an LD50 of ≥107 CFU.
Importantly in this regard, 2 studies in knockout mice lacking the p19 subunit of IL-23 showed marked attenuation of T cell mediated colitis, while knockout of the p35 subunit of IL-12 produces no such attenuation, suggesting that IL-23 but not IL-12 is essential for the development of colitis.
Controlling for IQ led to marked attenuation of these gradients such that the percentage reduction in the hazard ratio ranged between199% and 86%.
Significant disease (stenosis ≥50%) was considered to be present in cases of obvious narrowing of the vessel or marked attenuation of coronary lumen signal[19].
In other areas of the arteries, there is often marked attenuation of media with gap formation only prevented by retained internal elastic and intima.
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