Sentence examples for marked and substantial from inspiring English sources

Patients with quinolone-resistant strains had a marked and substantial excess mortality, which could not be explained by imbalances in comorbidity.

Indications for LVRS/bullectomy: emphysema with destruction and marked hyperinflation; substantial bulla identified on CXR; a marked functional impairment; a marked reduction in activities of daily living; a failure of maximum medical treatment to reduce symptoms; heterogeneous disease with obvious apical target areas [ 7].

This switch in the relative levels of DCC and UNC5H takes place during a critical developmental period marked by substantial reorganization and vulnerability of the mPFC DA system, which coincides with the onset of symptoms of many psychiatric disorders, including schizophrenia.

The past 10 years have been marked by substantial excitement — and more than a little hype — over the nation's possibilities.

The calculations were performed at five-year intervals; in the recent years, which have been marked by substantial mergers and acquisitions, we tried to obtain more frequent data points.

The text and syllabus marked a substantial departure from the original objective of keeping the first term close to Calculus 1. Adler begins with a precalculus review and an introduction to discrete dynamics.

Waage et al. also make reference to political influences on distribution in a cautionary comment on post-2015 development: 'aspirations for human development co-exist in a globalised political economy that is marked by substantial inequality and exploitation' (4 p. 1015).

Despite its prevalence and rising incidence, NAFLD is marked by substantial interpatient variability in prognosis and continues to lack the breadth of therapeutic research and development shared by other causes of chronic liver disease.

The eastern and northern shores and inlying areas were marked for "substantial rehabil itation," to keep or provide de sirable residential communi ties.

They have the basketball acumen to understand that, despite the loss, their team's effort marked a substantial step forward and deserved their praise.

The early postnatal period in both humans and rodents is marked by substantial brain development; however, the exact nature of the development is different.