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AO shows marked and prolonged accumulation in cancer cells, since these contain many strongly acidic lysosomes [ 133] and is, therefore, useful for visualizing tumor cells during surgery through a fluorescent microscope.
IL-6 caused impressively marked and prolonged elevations of plasma ACTH and cortisol on the first day, but blunted ACTH responses on the seventh day of treatment, perhaps as a result of increased baseline cortisol levels [ 16].
Marked and prolonged postprandial hypertriglyceridemia, characterized by the accumulation of apolipoprotein B-containing triglyceride-rich lipoproteins (TRL), is a significant contributor to the development of dyslipidemia and a known risk factor for atherosclerosis [2].
Conclusion Lithium overdose alters rat behaviour and consistently induces hypolocomotion which is more marked and prolonged in repeatedly lithium-treated rats.
The problem would be less severe in East Africa where there is a marked and prolonged dry period, with consequent absence of berries in the field for extended periods.
In Abl-proficient cells, paclitaxel produced a marked and prolonged G2/M arrest which peaked at 24 h and a rapid and marked induction of p21WAF1which also peaked at 24 h.
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However, we also found a deeply quiescent and viable fraction of cells that were marked by p21HIGH levels and prolonged H2B-GFP label retention.
They are more closely associated with intense airway inflammation, marked lymphocytosis, prolonged IL-5 and TGF-β1 production in the airways and a Th1 immune response.
beta-Endorphin produces marked, prolonged muscular rigidity and immobility similar to a catatonic state, counteracted by the opiate antagonist naloxone; this effect occurs at molar doses 1/100 to 1/400 that at which the other peptides or morphine block the response to painful stimuli.
The reaction was swift and prolonged.
Vowels are stretched and prolonged in speech.
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