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In contrast, the mature, peripheral B-cell compartment exhibits marked alterations with a reduction in the absolute numbers of splenic MZP/MZ B cells, peritoneal B1a B cells, and BM-derived recirculating mature B cells.
In contrast, the capillary network in both the SE-Aged and IM-Aged rats showed marked alterations, with a reduced capillary density and striking abnormalities in shape and 5(c)) compared to the SE-Young rats.
From the spatio-temporal drought analysis, temporal evolutions of SPI at 12 month aggregation show relatively wet conditions in the last two decades (although with marked alterations) with the 2012 2014 period being the wettest.
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Simultaneous flow cytometry analyses demonstrated marked alterations in immune cell numbers, with decreased central memory CD4 and CD8 T cells and increased numbers of monocytes.
Sepsis leads to endothelial damage, marked alterations in blood flow distribution and altered tissue oxygen metabolism, which are associated with high mortality rates among critically ill patients [ 1- 3].
As in adults, septic shock in pediatric patients induced marked alterations in immune parameters in accordance with the occurrence of a state of immunosuppression.
As marked alterations in ATP levels were noted with combination treatment, we assayed MiaPaca2 cells for glycolytic activity after β-lap+FK866 treatment.
Consistent with findings in mice, marked alterations in nuclear envelope morphology, abnormal localization of RanGAP1, and nuclear accumulation of mRNA were found in cortex of Huntington's disease patients.
Tissue factor showed marked alterations in response to chemotherapy in those with and without VTE at 3 months.
In general, more marked alterations were seen in Gpx1−/− as compared with WT mice, supporting the role of Gpx1 in cellular defense against oxidant stress to cope with aberrant gene expression.
Furthermore, a GFP-DRH-1 fusion protein did not show marked alterations in expression levels or subcellular localization upon infection with the Orsay virus (our unpublished observations).
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