Sentence examples for marked alterations to from inspiring English sources

These remarkable findings have come from observations that patients with compromised sperm epigenomes tend to have decreased fertility in general, but also have higher likelihood of having marked alterations to sperm function and poor pregnancy outcomes.

Therefore, under the low reproductive hormone levels of hpg mice, immunostaining revealed marked alterations to the maturation of both female and male AVPV kisspeptin populations.

These mice showed loss of RGCs from the peripheral retina within the first 3 months of diabetes, as well as marked alterations to the morphology of surviving cells (Gastinger et al., 2008).

Tissue factor showed marked alterations in response to chemotherapy in those with and without VTE at 3 months.

Thus, findings presented here suggest that injection heroin use among HIV-infected individuals promote increased reductions in the albumin levels and marked alterations in the albumin to total protein ratio.

Sepsis leads to endothelial damage, marked alterations in blood flow distribution and altered tissue oxygen metabolism, which are associated with high mortality rates among critically ill patients [ 1- 3].

Importantly, marked alterations in metabolic pathways in response to the intracellular environment were also evident such as elevated levels of glycogen biosynthesis and mixed acid fermentation enzymes.

Under non-diabetic conditions, FGF21KO mice did not show marked alterations in aortic wall thickness compared to the WT controls.

In contrast, the exchange of the phenylalanine by glycine introduces marked alterations (Fig 1B) as this mutant shows no binding to PG but to all galactolipids.

The present study was designed to study aluminum chloride which caused marked alterations in biochemical parameters such as glutathione peroxidase, catalase, superoxide dismutase, and TBARS in brain tissues of mice.

In contrast, we and others have observed marked alterations in the metabolic markers, especially tHcy, in relation to age and sex (32, 14).