The phrase 'marked activation of' is correct and usable in written English.
The phrase generally means that something has been noticeably or strongly active and can be used in many contexts. For example, "The marked activation of the immune system brought on by the virus caused a rapid fever."
For instance, PKA and PKC are phosphorylated at Thr and Thr [PKC βII], respectively, corresponding to Thr of hMyo3A, in the activation loop catalyzed by PDK1, which causes marked activation of the kinase activity.
Cardiac surgery with cardiopulmonary bypass (CPB) is associated with major inflammatory triggers that cause marked activation of the microcirculation.
There was marked activation of the subepithelial and perimuscular prostatic telocytes in the castrated animals after 3 days of testosterone replacement.
Similarly, dATP as well as ATP caused marked activation of IMP dephosphorylation by a lymphoblast cytoplasmic nucleotidase.
In contrast to conventional CD4+ T cells, Treg exhibited marked activation of the p38 MAP kinase pathway.
In addition to immune cells, marked activation of epithelial cells was another important characteristics of allergic diseases and substantial evidence has demonstrated that epithelial cells are able to mediate and regulate both innate and adaptive immune responses [12], indicating that malfunction of epithelia cells is involved in the initial cause of allergic diseases.
As expected, chronic CCl4 administration to C/EBPβ+/+ (wt) mice, induced marked activation of HSC, as indicated by the positive immunofluorescence for α-SMA within the scar tissue [5] [6] (Figure 4A), and proliferation of HSC, as indicated by the presence of proliferating cell nuclear antigen (PCNA; DNA polymerase δ auxiliary protein), an S-phase marker [28] (Figure 4B).
Tak ∆Hep livers showed marked activation of the Smad 2/3 pathway.
Our previous studies found marked activation of cyclin D with toxicity and pathogens [ 46, 47].
However, in the upper leg, compared with NDC subjects, subjects with diabetes exhibited marked activation of MMPs.
Paws of hTNFtg mice exhibited marked activation of both p38MAPKα and ERK (Fig. 1a,c) compared with wild-type mice.
