IHC performed on transverse sections of lkb1 intestine and liver confirmed a marked accumulation of p62 in lkb1 larvae, whereas wt siblings were devoid of staining (Fig. 1F,G).
NAP1L3 knockdown resulted in a marked accumulation of UCB HSCs in the G0 phase of the cell cycle (25%) compared to control cells (15%), at four days after transduction.
The number of Tregs increased in hyperplasias and dysplasias of Krt76−/− tongue compared to controls and there was a marked accumulation of Tregs in tumour stroma (Fig. 6e, g, arrowheads, h).
These studies revealed that the tissue response to disease is characterized by a marked accumulation of cardiovascular cells associated with inflammation, neovascularization, matrix production, eventually fibrosis, and in some cases calcification.
When compared to saline, nitrate alone markedly lowered rumen methane production and caused a marked accumulation of rumen and plasma nitrite, and formation of blood methemoglobin consequently reduced oxygen consumption, carbon dioxide production, and metabolic rate.
Interestingly, chilling resulted in rapid and marked accumulation of VrLTP1 transcripts in NM94 but less in its parental lines VC1973A, 6601 and VC2768A (Fig. 3b; Table 1).
If this method was not followed, the fermentation would fail because of marked accumulation of decanoic acid and loss of the cell viability (Additional file 1: Figure S2).
CRISPR/Cas9-mediated knock-in of Rpt3-T25A mutation, which reduces endogenous proteasome activity, causes marked accumulation of cell cycle inhibitors such as p21Cip1 and p27Kip1 during S-to-G2/M transition and impedes cell proliferation.
This is despite the increased numbers of pyknotic neurons and marked accumulation of inclusions in the cells in the SCN.
In OVA-sensitized mice, OVA feeding caused marked accumulation of CD3+ and osteopontin+ cells in mesenteric adipose tissue.
ΔN141 and ΔN197 mutations caused a marked accumulation of MHC-IIB in the posterior end of polarized cells.
