Sentence examples for mark was observed from inspiring English sources
A TP mark was observed on 319 out of the 360 cancers (89%).
In contrast, a slight decrease in the H3K9me2 mark was observed when cells were treated with 2.5 μM PG-11144 alone.
Average chromatin state frequencies differed between promoters with DMRs and all autosomal RefSeq promoters, in that an increase of 'Inactive/poised promoter' marks, mainly at the expense of the 'Active promoter' mark, was observed in areas having DMR overlaps.
In addition to DNA hypomethylation, loss of the repressive H3K27me3 and H4K20me3 histone mark was observed in CLDN4-expressing cells (SNU119 and Caov3), as compared with CLDN4-repressed cells.
Importantly, no detection of the H3K27me3 mark was observed in Ci-e z) morphants (Fig. 4 right panels), demonstrating that Ci-e z) is the only histone K27-specific morphantsnsFigase, as already observed in humans (Ferrari et al., 2014).
DOI: http://dx.doi.org/10.7554/eLife.03397.013 The results indicate that DNA methylation is dominant over both H3K4me3 and H3K27me3, as in its presence neither chromatin mark is observed at the artificial CGIs.
Stable, long-term, polyclonal high-level gene marking was observed using relatively low multiplicities of infection (MOI s, and transgene expression was detected in all lineages.
No loss of any marks was observed during the study by both visual inspection and validation using digital shell fingerprint images.
Although a reduction in enrichment for these active chromatin marks was observed at some regulatory sites of the β-globin locus they were considerably more enriched than inactive loci such as Necdin, βh1 and Amylase.
A similar percentage of these marks was observed in the consensus ESC genes in our study that were upregulated in NTERA-2 with respect to ASC (n = 554, detected by SAM analysis) (Figure 3A) (Table S5).
However, significant increase in hypermethylation of H3K9me3/H3K27me3, repression marks, was observed after bleomycin drug treatment.
