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Mark demonstrated that these 'nanosolutions' reduce in vivo tumor burden in models of hepatocellular carcinoma (HCC), and breast/pancreatic/melanoma cancer as well as leukemias.
The findings were unlikely to result from changes in sympathetic tone, as Takeshita and Mark demonstrated that peak blood flow responses following 10 min ischemic stimuli were not altered by lower body negative pressure induced increases in sympathetic outflow (Sinoway et al. 1986; Takeshita and Mark 1980).
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Genome-wide analyses of epigenetic marks demonstrated that these gene families are regulated by tri-methylation of lysine 9 at the amino-terminal tails of histone H3 (H3K9m) [ 10, 11], a conserved modification that confers variegated gene expression in many eukaryotic organisms [ 12].
Brand demonstrated that TAL1 recruits UTX, which sustains gene activation by removal of the H3K27me3 mark.
The 20% least expressed genes show little or no signal for RNAPII, PRCs, or mapped histone marks, demonstrating that ESCs harbor a large group of genes silent in the absence of RNAPII or PRC marks.
Longo et al. demonstrated that ruptured tendons exhibit marked histopathologic changes in comparison to cadaveric tendons [ 13].
Evaluation questionnaires and performance marks have demonstrated that the training package has worked well, and student comments (File S2) have indicated ways to improve this experience even further, as will be detailed next.
"They need to step-up to the mark and demonstrate that they are capable of improving".
Using a mark-recapture experiment, Gagliano demonstrated that eyespots of the Ambon damselfish (Pomacentrus amboinensis) may not confer the long-assumed protection from predators and suggested that these markings may serve other purposes.
Studies with retrovirally marked clonal mammary populations demonstrated that both of these lineage-limited activities were present within the clonal populations through repeated transplant generations, indicating their derivation from a single pluripotent antecedent [ 10, 13].
These findings contrast those of earlier studies, which demonstrated that marked reduction in viral load and magnitude of change in CD4+ cell counts is associated with IRIS risk [ 44].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com