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The phrase "mark a significant step" is grammatically correct and usable in written English.
It can be used to indicate that something is an important or groundbreaking action or event. Example: The signing of the peace treaty marked a significant step towards ending the long-standing conflict between the two countries. In this sentence, "mark a significant step" is used to show that the signing of the treaty is a significant action that moves the situation closer to a resolution.
Exact(17)
Victory would mark a significant step in the battle for equal pay, said Newman.
This success, the topic of a recent paper in Proceedings of the National Academy of Sciences, could mark a significant step forward for gene therapy.
The death of the elusive leader would mark a significant step change in the US-led effort to curtail the Islamist extremist group.
Should a large number of Democratic candidates lose, it would mark a significant step in one of the most fundamental, if slow-moving, political realignments in American politics.
A greater commitment to implementing meaningful CSR programmes by the hundreds of global corporations present on the continent would mark a significant step towards meeting these targets and help put Africa on the road to a prosperous future.
Inclusion of sediment-generation modules in models of landscape evolution and basin filling will mark a significant step towards full-fledged "source-to-sink" simulations of earth-surface processes.
Similar(43)
Though the agreement is preliminary, it marks a significant step forward.
The Islamic State's public creation of this Amaq site on ZeroNet marks a significant step.
He says today marks a significant step in the Brexit process.
This marks a significant step in resolving our mortgage-related exposures".
EU officials insisted that Tuesday's decision on sanctions marked a significant step towards new punitive measures.
More suggestions(15)
mark a significant shift
mark a giant step
mark a positive step
mark a modest step
mark a crucial step
mark a critical step
mark a tentative step
mark a significant turnaround
mark a final step
mark a significant resolution
mark a noticeable step
mark a big step
mark a significant setback
mark a significant expansion
mark a welcome step
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com