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In patients with a favourable or intermediate prognosis, tumour-free margins were associated with favourable survival and local tumour control; having a wide surgical margin compared with an intralesional margin improved 5-year overall survival significantly from 11%to3131% (P = 0.028 24.
The MPR data found that poorly defined 3D nodule margins were associated with malignancy but also described two novel, independent 3D predictors of malignancy: a lobulated nodule shape in the C-plane (coronal) and altered central 3D vascularity.
Positive margins were associated with LR (hazard ratio (HR)=4.790, 95% confidence interval (CI) 1.696 13.531).
Furthermore, molecularly positive surgical margins were associated with decreased time to disease-specific deaths (P=0.013, Kaplan Meier analysis with log-rank test, Figure 2B).
Log-rank analyses showed that molecularly positive margins were associated with shorter time to local recurrences and disease-specific deaths (P=0.03 and 0.01, respectively).
In this cohort, younger age, a larger tumor size, a higher tumor grade, and positive margins were associated with lower rates of LRFS.
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Likewise, wider margins are associated with increases in the threshold of stability criteria.
In addition, positive resection margins are associated with an increased long-term risk of disease recurrence in patients who have undergone breast-conserving therapy [49].
Combined, they take account of transfer costs in a broad sense.10 The margin demand equations in the model show that the demands for margins are proportional to the commodity flows with which the margins are associated; moreover, a technology change component allows changes in the implicit transportation rate.11.11
The evidence that wider margins is associated with better local control rates does not stand up to scrutiny.
The presence of positive surgical margins is associated with a higher risk of local disease relapse [ 3, 16– 16].
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CEO of Professional Science Editing for Scientists @ prosciediting.com