It has been dissected into rolling hills by streams, but its margins are marked by steep cliffs.
To maintain orientation, tumor margins were marked on the corresponding H&E-stained slide.
Lesion margins were marked and then measured 10-14 days later for the longitudinal extension with a digital caliper.
Three representative areas from the tumor center and invasive margins were marked by a board certified pathologist (W.W).
For quality control, circumferential resection margins are marked intraoperatively, and representative histological sections will be centrally reviewed by a dedicated pathologist.
Prior to the incision, margins were marked using 4 W continuous wave (CW) mode and 0.2 mm spot diameter (SD) guideline around the mass.
Representative areas from the tumour centre and invasive margins were marked by pathologists with special expertise in BTC pathology (BG and WW).
The scleral defect size was measured and its margin was marked with a biopsy punch.
To determine the boundary for the conjunctivectomy, the size of the scleral defect was measured and its margin was marked with a 3-mm diameter biopsy punch (Fig. 2a, b).
The continental edge of the Western Iberian Margin is marked by two contrasting basins, the mostly onshore Lusitanian Basin and the mostly deepwater Peniche Basin.
