It is the unexpected result of a "marginal revolution" with trials and errors led by "top design".
The data were organized into a 2×2 contingency table with the marginal totals for the number of trials fixed (Tables 1 and 2).
This family background, Mr. Ginzburg acknowledges, awakened his interest in the history of trials of marginal groups like lepers, witches and Jews.
Meta-analysis of prospective trials reporting marginal bone loss with one-year follow-up was also reported.
To date, only Pfs25 and Pvs25 (P. vivax homolog of Pfs25) have undergone limited Phase I clinical trials with marginal success [11], [12].
For other autoimmune diseases that are in dire need of safer and/or more effective therapies, the anti-BAFF antibody belimumab, despite showing marginal efficacy in clinical trials, was approved for treatment of systemic lupus erythematous (SLE).
This analysis revealed a main effect of trial, as expected, F7,35 = 342.3, P < 0.0005, a marginal effect of test phase, F1,5 = 4.55, P = 0.086, and a test phase by trial interaction, F7,35 = 2.29, P = 0.05.
"The results of the first trial were marginal, and obviously the drug was just not sufficiently potent," he said.
The smaller trial was only partially blinded and showed no difference in any of the outcomes; the large trial demonstrated marginal reduction in proportional hematoma growth, but no significant difference in clinical outcome.
It is expected that over the duration of the trial, positive marginal biopsy rates for an individual surgeon will not exceed 10%%.
